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Darren M. Smith, MD, FACS

Darren M. Smith, MD, FACS

Research &
Publications

Dr. Darren M. Smith’s academic work spans aesthetic surgery, craniofacial surgery, reconstructive research and surgical education. Explore selected work by topic, or browse the bibliography below.

Explore the work

A closer look at the research.

Start with an area of interest. Each title leads to its full citation, with links to publication records where available.

The academic record

Academic bibliography.

Journal articles and reviews, commentary, books and editorial contributions, and textbook chapters are grouped separately. The patent and forthcoming chapter appear in their own sections.

Explore Dr. Smith’s journal articles, books and textbook chapters. Visit Press & Media for interviews and media coverage.

Journal articles and reviews

51 entries
  1. 2024

    Stein MJ, Smith D, Chia C, Matarasso A. Paradoxical adipose hyperplasia following cryolipolysis. Aesthetic Surgery Journal. 2024;44(10):1063–1071.

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  2. 2022

    Smith DM. The role of energy-based devices in male body contouring. Clinics in Plastic Surgery. 2022;49(2):329–337.

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  3. 2019

    Bykowski MR, Shakir S, Naran S, Smith DM, Goldstein JA, Grunwaldt L, Saladino RA, Losee JE. Pediatric Dog Bite Prevention: Are We Barking Up the Wrong Tree or Just Not Barking Loud Enough? Pediatric Emergency Care. 2019;35(9):618-623.

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  4. 2017

    MacIsaac ZM, Henderson SE, Shakir S, Naran S, Smith DM, Camison L, Cray JJ, Almarza AJ, Cooper GM, Losee JE. Biomechanical integrity in craniofacial surgery: Calvarial reconstruction in favorable and infected defects with bone morphogenetic protein 2. Plastic and Reconstructive Surgery. 2017;139(5):1141-1150.

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  5. 2017

    Rottgers SA, Gallo P, Gilbert J, Macisaac Z, Cray J, Smith DM, Mooney MP, Losee JE, Kathju S, Cooper G. Application of laser capture microdissection to craniofacial biology: characterization of anatomically relevant gene expression in normal and craniosynostotic rabbit sutures. The Cleft Palate-Craniofacial Journal. 2017;54(1):109-118.

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  6. 2016

    Nguyen PD, Caro MC, Smith DM, Tompson B, Forrest CR, Phillips JH. Long-term Orthognathic Surgical Outcomes in Treacher Collins Patients. Journal of Plastic, Reconstructive and Aesthetic Surgery. 2016;69(3):402-408.

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  7. 2016

    MacIsaac ZM, Shakir S, Naran S, Smith DM, Cray JJ, Nayar HS, Camison L, Kinsella CR Jr, Mooney MP, Cooper GM, Losee JE. Repair of a Complicated Calvarial Defect: Reconstruction of an Infected Wound With rhBMP-2. Annals of Plastic Surgery. 2016;76(2):205-210.

    Publication record
  8. 2015

    Matarasso A, Smith DM. Combined Breast Surgery and Abdominoplasty: Strategies for Success. Plastic and Reconstructive Surgery. 2015;135(5):849e-860e.

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  9. 2015

    Davidson EH, Schuster L, Rottgers SA, Smith DM, Naran S, Goldstein JA, Losee JE. Severe Pediatric Midface Trauma: A Prospective Study of Growth and Development. Journal of Craniofacial Surgery. 2015;26(5):1523-1528.

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  10. 2015

    Matarasso A, Smith DM. Strategies for Aesthetic Reshaping of the Postpartum Patient. Plastic and Reconstructive Surgery. 2015;136(2):245-257.

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  11. 2015

    Aston SJ, Smith DM. Taking it on the Chin: Recognizing and Accounting for Lower Face Asymmetry in Chin Augmentation and Genioplasty. Plastic and Reconstructive Surgery. 2015;135(6):1591-1595.

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  12. 2015

    Shakir S, MacIsaac ZM, Naran S, Smith DM, Bykowski MR, Cray JJ, Craft TK, Wang D, Weiss L, Campbell PG, Mooney MP, Losee JE, Cooper GM. Transforming Growth Factor Beta 1 Augments Calvarial Defect Healing and Promotes Suture Regeneration. Tissue Engineering Part A. 2015;21(5-6):939- 947.

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  13. 2014

    Cray JJ, Henderson SE, Smith DM, Kinsella CR, Bykowski M, Cooper GM, Almarza AJ, Losee JE. BMP-2-Regenerated Calvarial Bone: A Biomechanical Appraisal in a Large Animal Model. Annals of Plastic Surgery. 2014;73(5):591-597.

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  14. 2014

    Rottgers SA, Cray JJ, Smith DM, Mooney MP, Losee JE, Cooper GM. Bone Morphogenetic Protein 2- Mediated Mandible Reconstruction Successfully Heals Bony Defects But Inhibits Concurrent Inferior Alveolar Nerve Grafting: A Rabbit Experimental Model. Journal of Craniofacial Surgery. 2014;25:2241- 2245.

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  15. 2014

    Smith DM, Losee JE. Cleft Palate Repair. Clinics in Plastic Surgery. 2014;41(2):189-210.

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  16. 2014

    Kinsella CR Jr, Castillo N, Naran S, Smith DM, DeCesare GE, Cladis FP, Ford MD, Vecchione L, Jiang S, Losee JE. Intraoperative high-dose epinephrine infiltration in cleft palate repair. Journal of Craniofacial Surgery. 2014;25(1):140-142.

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  17. 2014

    Naran S, Keating J, Natali M, Bykowski M, Smith DM, Martin B, Losee JE. The safe and efficacious use of arch bars in patients during primary and mixed dentition: a challenge to conventional teaching. Plastic and Reconstructive Surgery. 2014;133(2):364-366.

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  18. 2013

    Smith DM, Bykowski MR, Cray JJ, Naran S, Rottgers SA, Shakir S, Vecchione L, Schuster L, Losee JE. 215 mandible fractures in 120 children: demographics, treatment, outcomes, and early growth data. Plastic and Reconstructive Surgery. 2013;131(6):1348-1358.

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  19. 2013

    MacIsaac ZM, Levine BA, Smith DM, Cray JJ, Shaw M, Naran S, Kinsella C, Mooney MP, Cooper GM, Losee JE. Novel Animal Model of Calvarial Defect: Part IV. Reconstruction of a Calvarial Wound Complicated by Durectomy. Plastic and Reconstructive Surgery. 2013;131(4):512e-519e.

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  20. 2012

    Lin AY, Kinsella CR Jr, Rottgers SA, Smith DM, Grunwaldt LJ, Cooper GM, Losee JE. Custom porous polyethylene implants for large-scale pediatric skull reconstruction: early outcomes. Journal of Craniofacial Surgery. 2012;23(1):67-70.

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  21. 2012

    Kinsella CR Jr, MacIsaac ZM, Cray JJ, Smith DM, Rottgers SA, Mooney MP, Cooper GM, Losee JE. Novel animal model of calvarial defect: part III. Reconstruction of an irradiated wound with rhBMP-2. Plastic and Reconstructive Surgery. 2012;130:643e-650e.

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  22. 2012

    Kinsella CR Jr, Cray JJ, Smith DM, Rottgers SA, Mooney MP, Cooper GM, Losee JE. Novel model of calvarial defect in an infected unfavorable wound: reconstruction with rhBMP-2. part II. Journal of Craniofacial Surgery. 2012;23(2):410-414.

    Publication record
  23. 2012

    Smith DM, Cray JJ, Weiss LE, Dai Fei Elmer Ker, Shakir S, Rottgers SA, Losee JE, Campbell PG, Cooper GM. Precise control of osteogenesis for craniofacial defect repair: the role of direct osteoprogenitor contact in BMP-2-based bioprinting. Annals of Plastic Surgery. 2012;69(4):485-488.

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  24. 2012

    Hurwitz D, Smith DM. Treatment of overweight patients by radiofrequency-assisted liposuction (RFAL) for aesthetic reshaping and skin tightening. Aesthetic Plastic Surgery. 2012;36(1):62-71.

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  25. 2011

    Losee JE, Smith DM. Acellular dermal matrix in palatoplasty. Aesthetic Surgery Journal. 2011;31(7 Suppl):108S-115S.

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  26. 2011

    Rottgers SA, Ford M, Cray JJ, Smith DM, Kinsella C, Grunwaldt L, Losee JE. An Algorithm for Application of Furlow Palatoplasty to the Treatment of Velocardiofacial Syndrome–Associated Velopharyngeal Insufficiency. Annals of Plastic Surgery. 2011;66:479-484.

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  27. 2011

    Kinsella CR Jr, Bykowski MR, Lin AY, Cray JJ, Durham EL, Smith DM, DeCesare GE, Mooney MP, Cooper GM, Losee JE. BMP-2-mediated regeneration of large-scale cranial defects in the canine: an examination of different carriers. Plastic and Reconstructive Surgery. 2011;127(5):1865-1873.

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  28. 2011

    DeCesare GE, Cooper GM, Smith DM, Cray JJ, Durham EL, Kinsella CR Jr, Mooney MP, Losee JE. Novel animal model of calvarial defect in an infected unfavorable wound: reconstruction with rhBMP-2. Plastic and Reconstructive Surgery. 2011;127(2):588-594.

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  29. 2011

    Rottgers SA, DeCesare G, Chao M, Smith DM, Cray JJ, Naran S, Vecchione L, Grunwaldt L, Losee JE. Outcomes in pediatric facial fractures: early follow-up in 177 children and classification scheme. Journal of Craniofacial Surgery. 2011;22(4):1260-1265.

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  30. 2011

    Grunwaldt L, Smith DM, Zuckerbraun NS, Naran S, Rottgers SA, Bykowski M, Kinsella C, Cray JJ, Vecchione L, Saladino RA, Losee JE. Pediatric facial fractures: demographics, injury patterns, and associated injuries in 772 consecutive patients. Plastic and Reconstructive Surgery. 2011;128(6):1263-1271.

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  31. 2011

    Kinsella CR Jr, Cray JJ, Durham EL, Burrows AM, Vecchione L, Smith DM, Mooney MP, Cooper GM, Losee JE. Recombinant Human Bone Morphogenetic Protein-2–Induced Craniosynostosis and Growth Restriction in the Immature Skeleton. Plastic and Reconstructive Surgery. 2011;127(3):1173-1181.

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  32. 2011

    Smith DM, Cooper GM, Afifi AM, Mooney MP, Cray JJ, Rubin JP, Marra KG, Losee JE. Regenerative surgery in cranioplasty revisited: the role of adipose-derived stem cells and BMP-2. Plastic and Reconstructive Surgery. 2011;128(5):1053-1060.

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  33. 2010

    Clavijo-Alvarez JA, Vecchione L, DeCesare G, Irwin C, Smith DM, Grunwaldt LJ, Losee JE. Autologous bone grafting with adjunctive use of acellular dermal matrix for alveolar cleft defects: early outcomes. The Cleft Palate-Craniofacial Journal. 2010;47(2).

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  34. 2010

    Vecchione L, Smith DM, Losee JE. Neonatal mandibular molding: A novel method of treating congenital open bite. Plastic and Reconstructive Surgery. 2010;125(2):648-651.

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  35. 2009

    Miljkovic ND, Cooper GM, Hott SL, DiSalle BF, Gawalt ES, Smith DM, McGowan K, Marra KG. Calcium Aluminate, RGD-Modified Calcium Aluminate, and β-Tricalcium Phosphate Implants in a Calvarial Defect. Journal of Craniofacial Surgery. 2009;20(5):1538-1543.

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  36. 2009

    Chao MT, Jiang S, Smith DM, DeCesare GE, Cooper GM, Pollack IF, Girotto J, Losee JE. Demineralized bone matrix and resorbable mesh bilaminate cranioplasty: a novel method for reconstruction of large-scale defects in the pediatric calvaria. Plastic and Reconstructive Surgery. 2009;123(3):976-982.

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  37. 2009

    Alef M, Irwin C, Smith DM, Afifi A, Jiang S, Vecchione L, Ford M, DeCesare GE, Deleyiannis FW-B, Losee JE. Nasal tip complications of primary cleft lip nasoplasty. Journal of Craniofacial Surgery. 2009;20:1327-1333.

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  38. 2008

    Losee JE, Smith DM, Afifi AM, Jiang S, Ford M, Vecchione L, Cooper GM, Naran S, Mooney MP, Serletti JM. A successful algorithm for limiting postoperative fistulae following palatal procedures in the patient with orofacial clefting. Plastic and Reconstructive Surgery. 2008;122(2):544-554.

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  39. 2008

    Smith DM, Afifi AM, Cooper GM, Mooney MP, Marra KG, Losee JE. BMP-2-based repair of large-scale calvarial defects in an experimental model: regenerative surgery in cranioplasty. Journal of Craniofacial Surgery. 2008;19(5):1315-1322.

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  40. 2008

    Smith DM, Cooper GM, Mooney MP, Marra KG, Losee JE. Bone morphogenetic protein 2 therapy for craniofacial surgery. Journal of Craniofacial Surgery. 2008;19(5):1244-1259.

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  41. 2008

    Tomiyama K, Murase N, Stolz DB, Toyokawa H, O’Donnell DR, Smith DM, Dudas JR, Rubin JP, Marra KG. Characterization of transplanted green fluorescent protein+ bone marrow cells into adipose tissue. Stem Cells. 2008;26(2):330-338.

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  42. 2008

    Dudas JR, Losee JE, Penascino VM, Smith DM, Cooper GM, Mooney MP, Jiang S, Rubin JP, Marra KG. Leporine-derived adipose precursor cells exhibit in vitro osteogenic potential. Journal of Craniofacial Surgery. 2008;19(2):360-368.

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  43. 2008

    Losee JE, Afifi A, Jiang S, Smith D, Chao MT, Vecchione L, Hertle R, Davis J, Naran S, Hughes J, Paviglianiti J, Deleyiannis FW. Pediatric orbital fractures: classification, management, and early follow-up. Plastic and Reconstructive Surgery. 2008;122(3):886-897.

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  44. 2008

    Weinzweig J, Panter KE, Patel J, Smith DM, Spangenberger A, Freeman MB. The fetal cleft palate: v. elucidation of the mechanism of palatal clefting in the congenital caprine model. Plastic and Reconstructive Surgery. 2008;121(4):1328-1334.

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  45. 2008

    Afifi AM, Mahboub TA, Losee JE, Smith DM, Khalil HH. The reverse sural flap: modifications to improve efficacy in foot and ankle reconstruction. Annals of Plastic Surgery. 2008;61(4):430-436.

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  46. 2007

    Smith DM, Oliker A, Carter CR, Kirov M, McCarthy JG, Cutting CB. A virtual reality atlas of craniofacial anatomy. Plastic and Reconstructive Surgery. 2007;120(6):1641-1646.

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  47. 2007

    Smith DM, Vecchione L, Jiang S, Ford M, Deleyiannis FWB, Haralam MA, Naran S, Worrall CI, Dudas JR, Afifi AM, Marazita ML, Losee JE. The Pittsburgh Fistula Classification System: a standardized scheme for the description of palatal fistulas. The Cleft Palate-Craniofacial Journal. 2007;44(6):590-594.

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  48. 2005

    Dayan JH, Smith D, Oliker A, Haring J, Cutting CB. A virtual reality model of eustachian tube dilation and clinical implications for cleft palate repair. Plastic and Reconstructive Surgery. 2005;116(1):236-241.

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  49. 2005

    Smith DM, Aston SJ, Cutting CB, Oliker A. Applications of virtual reality in aesthetic surgery. Plastic and Reconstructive Surgery. 2005;116(3):898-904.

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  50. 2005

    Smith DM, Aston SJ, Cutting CB, Oliker A, Weinzweig J. Designing a virtual reality model for aesthetic surgery. Plastic and Reconstructive Surgery. 2005;116(3):893-897.

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  51. 2002

    Cutting C, Oliker A, Haring J, Dayan J, Smith DM. Use of three-dimensional computer graphic animation to illustrate cleft lip and palate surgery. Computer Aided Surgery. 2002;7(6):326-331.

    Publication record
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Discussions, editorials and replies

7 entries
  1. 2019

    Smith DM. Commentary on: The new frontier: A review of augmented reality and virtual reality in plastic surgery. Aesthetic Surgery Journal. 2019;39(9):1017-1018.

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  2. 2016

    Matarasso A, Smith DM. Reply: Combined Breast Surgery and Abdominoplasty: Strategies for Success. Plastic and Reconstructive Surgery. 2016;137(1):249e-250e.

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  3. 2013

    Smith DM, MacIsaac ZM, Losee JE. Discussion: Limited Evidence for the Effect of Presurgical Nasoalveolar Molding in Unilateral Cleft on Nasal Symmetry: A Call for Unified Research. Plastic and Reconstructive Surgery. 2013;131(1):72e-74e.

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  4. 2013

    Rubin JP, Smith D. Discussion: percutaneous aponeurotomy and lipofilling: a regenerative alternative to flap reconstruction? Plastic and Reconstructive Surgery. 2013;132(5):1291-1292.

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  5. 2012

    Smith DM, Gorantla VS, Losee JE. Craniofacial transplantation: seeing the whole picture. [Editorial.] Imaging in Medicine. 2012;4(2):147-149.

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  6. 2012

    Nischal KK, Smith DM, Losee JE. Discussion: Nocturnal Ultrasound Measurements of Optic Nerve Sheath Diameter Correlate with Intracranial Pressure in Children with Craniosynostosis. Plastic and Reconstructive Surgery. 2012;130(3):452e-454e.

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  7. 2009

    Losee JE, Smith DM. Application-Specific Selection of Biomaterials for Pediatric Craniofacial Reconstruction: Developing a Rational Approach to Guide Clinical Use (Invited Discussion). Plastic and Reconstructive Surgery. 2009;123:1123-1124.

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Books and editorial contributions

2 entries
  1. 2015

    Losee JE, Kirschner RE, Smith DM, Straub AE, Lawrence C, eds. Comprehensive Cleft Care: Family Edition. CRC Press / Taylor & Francis Group; 2015.

    Book record
  2. 2012

    Neligan PC, ed. Plastic Surgery. 3rd ed. Elsevier Saunders; 2012. Technical copy editors: Smith DM, Woon C.

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Book chapters and chapter discussions

12 entries
  1. 2026

    Matarasso A, Smith DM. Male Abdominoplasty. In: Jeffords K, Manders EK, Austen WG Jr, eds. Aesthetic Surgery for Men. Springer, Cham; 2026:377–387.

    Publication record
  2. 2024

    Smith DM. Unique Anatomy of the Male Torso and Extremities. In: Thaller SR, Cohen MN, eds. A Comprehensive Guide to Male Aesthetic and Reconstructive Plastic Surgery. Springer, Cham; 2024:15–18.

    Publication record
  3. 2023

    Matarasso A, Smith DM. Establishing a Post-maternity Strategy. In: Gomes-Ferreira M, Olivas-Menayo J, eds. Post-maternity Body Changes. Springer, Cham; 2023:157–171.

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  4. 2019

    Matarasso A, Smith DM. The Aging Neck. In: Evans GRD, ed. Operative Plastic Surgery. 2nd ed. Oxford University Press; 2019. Chapter 28.

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  5. 2018

    Matarasso A, Smith DM. Abdominoplasty (Discussion). In: Cohen MN, Thaller SR, eds. The Unfavorable Result in Plastic Surgery: Avoidance and Treatment. 4th ed. Thieme; 2018.

  6. 2016

    Nguyen PD, Smith DM, Forrest CR. Craniosynostosis. In: Bentz ML, Bauer BS, Zuker RM, eds. Principles and Practice of Pediatric Plastic Surgery. 2nd ed. CRC Press; 2016.

  7. 2016

    Smith DM, Nguyen PD, Forrest CR. Secondary Cleft Rhinoplasty. In: Rohrich RJ, Ahmad J, eds. Secondary Rhinoplasty by the Global Masters. 1st ed.; 2016. Chapter 24.

    Book record
  8. 2015

    Monson LA, Smith DM, Losee JE. Pediatric Facial Fractures. In: Taub PJ, Patel PK, Buchman SR, Cohen MN, eds. Ferraro’s Fundamentals of Maxillofacial Surgery. 2nd ed. Springer, New York; 2015:283–297.

    Publication record
  9. 2015

    Smith DM, et al. Post-Palatoplasty Fistulae: Diagnosis, Treatment, and Prevention. In: Losee JE, Kirschner RE, eds. Comprehensive Cleft Care. 2nd ed.; 2015.

  10. 2012

    Losee JE, Smith DM. Pediatric Facial Fractures. In: Neligan PC, ed. Plastic Surgery. 3rd ed. Vol. 3. Elsevier Saunders; 2012:671–685.

  11. Losee JE, Smith DM. Cleft Palate Repair. In: Butler CE, ed. Head and Neck Reconstruction with DVD: A Volume in the Procedures in Reconstructive Surgery Series. Saunders / Elsevier. pp. 271–294.

    Book record
  12. Losee JE, Smith DM, Vecchione L, Afifi AM, Ford MD. Post-Palatoplasty Fistulae: Diagnosis, Treatment, and Prevention. In: Losee JE, Kirschner RE, eds. Comprehensive Cleft Care. 1st ed. McGraw-Hill Medical. pp. 525–554.

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Patent

1 entry
  1. 2011

    Weinzweig J, Smith D, inventors. Predicting Movement of Soft Tissue of the Face in Response to Movement of Underlying Bone. United States Patent US 7,953,260 B2. Granted May 31, 2011. Computer software for craniofacial surgical planning.

    Patent record
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Forthcoming work

1 entry
  1. Forthcoming

    Chapter contribution on the Preservé breast augmentation technique. In: Expert Techniques in Aesthetic Surgery. Elsevier. Forthcoming.

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